Affinity of Thiamine Propyl Disulfide-s35 to Blood.

The fact that the tissue affinity of thiamine propyl disulfide (TPD) is superior to that of thiamin hydrochloride has been shown by many studies in this country as well as in foreign countries. Especially, the distribution of thiamine in the blood after administration of TPD is worthy of note, i.e., the thiamine concentra tion in the blood, particularly in blood cells, is markedly higher after administra tion of TPD than after administration of thiamine hydrochloride. However, the mechanism of penetration of TPD into blood cells in such high concentrations remained to be elucidated. In order to clarify this, the authors gave TPD-S35 (outer), TPD-S35 (inner) and thiamine-S35 to animals under different conditions, investigated the distribution of both S35 and thiamin and obtained several interesting findings.